8/28/2023 0 Comments Paypal shipping![]() Based on the size and weight of the parcel and your budget, choose your shipping carrier.Click “order” of the desired transaction.Go to the “Activity” section and browse the most recent transactions.If you have completed the transaction, then you can easily create PayPal shipping labels by following the given steps: ![]() HOW TO CREATE A PAYPAL SHIPPING LABEL WITH AN INVOICE? Affix this printed label on the package to be shipped.Click “Print Label” to print out your shipping label.You will have the choice either to pay with your PayPal balance or your credit card. This will calculate the shipping cost based on the information (weight and measurements of the parcel) you have provided. Review all the information you provided, if all is correct then click “Calculate Shipping Cost” on the right-hand side of the screen.Now, fill out the required parcel information such as weight, measurements of the parcel, and shipping date.PayPal permits you to ship with USPS and UPS and provides many service options. Choose any of the two shipping services.This is the “return to sender” address if issues arise. Furthermore, enter the address you will be shipping from.A pop-up will appear, enter the recipient’s address and click “Ship To This Address”.Once logged in to your PayPal account, head to.HOW TO CREATE A SHIPPING LABEL WITH PAYPAL WITHOUT A PURCHASE, TRANSACTION, OR INVOICE?įollowing is the procedure to create a shipping label for a parcel that is not associated with PayPal transaction, or purchase: Stick the printed label on the parcel to be shipped.Tap on the “Print label” on the “Finish printing your label” page.Select either to pay with a credit card or your PayPal balance. Once you ensure that your information is correct, click “Confirm and Pay”.Enter and review the shipping information, then click “Calculate Shipping”.Choose the shipping carriers (either UPS or USPS).Choose the desired order to expand its details, and enter on “Print Shipping Label”.Click on the transaction for which you wish to create a label.Click the “Activity” tab on the top of the page and choose the item you want to ship.
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8/28/2023 0 Comments Bootstrap studio free download![]() This key is only provided to students, organization, institutions, and many other professional offices.īootstrap Studio Free Download Torrent facilitates you a registered user of the program. It gives you right on the key to own all intellectual property rights in the software. The license key validity is for one year then you to renew it. For instance, program owner facilitates their customer if they are students so it can be used in three computers of an institution. The application owners provide a license key only to the buyer. Basically, the application is only available for purchase and can be used in three computers. Bootstrap License Keyīootstrap Studio License Key gives you more updated and extra features to access more attractive designing. In addition, the program provides you basic and advanced elements like spans and divs. ![]() This application comes with multiple headers, footers, galleries, and slideshows. These components provide you with help to create an attractive website. In addition, the application gives you pretty powerful components. These templates consist of multiple pages and widgets that you can select and match into the outstanding website. It gives you a large number of premium and fully responsive templates. This studio comes with beautiful templates to easily customize. In addition, it is the best choice for prototyping, designing web pages, and applications. It is built around the simplicity of drag and drop that makes it a perfect tool. It enables you to beautifully design websites.įurthermore, this studio contains a powerful and beautiful interface. This program is easy to use and comes with a user-friendly interface. It helps you to exports clean and semantic HTML. This application is built on top of hugely worldwide familiar frameworks. It enables you to drag and drop to assemble responsive and impressive web pages. It provides you with a large number of powerful built-in components. In addition, this program provides you powerful desktop and framework. It helps you to create responsive websites with ease and professional styled. This application is the only solution for creating impressive websites. Bootstrap Studio 4.5.3 Crack + Torrent with License Keyīootstrap Studio 4.5.3 Crack is an application to design websites. 8/27/2023 0 Comments Passwordsafe download![]() It comes in both 32-bit and 64-bit downloads. Previous versions of the OS shouldn't be a problem with Windows 8 and Windows 7 having been tested. LSN Password Safe latest version: Simple password manager with spyware protection. Password Safe can be used on a computer running Windows 11 or Windows 10. LSN Password Safe, free and safe download. What version of Windows can Password Safe run on? Rony Shapiro accepts donations for the continued development of this free software. Download and installation of this PC software is free and 3.63.0 is the latest version last time we checked. Password Safe is provided under a freeware license on Windows from password software with no restrictions on usage.
8/27/2023 0 Comments Induced pluripotent![]() Platelets in wound healing and regenerative medicine. Transfusion guidelines: When to transfuse. Proceedings of the Society for Experimental Biology and Medicine, 78(3), 796–799. ![]() Separation, Concentration, and Transfusion of Platelets. (2019). 66 - Stem Cell-Derived Platelets, in Platelets (Fourth Edition), A.D. Platelet refractoriness–practical approaches and ongoing dilemmas in patient management. Platelet biology and functions: New concepts and clinical perspectives. Immortalize MK Progenitor Cell Line MK-FOP:Īntibody-dependent Cell-mediated Cytotoxicity FNAIT:įetal/neonatal Alloimmune Thrombocytopenia PTP: Vascular Endothelial Growth Factor ES-sacs:Ĭanine Induced Pluripotent Stem Cells imMKCLs: Transfusion-Related Acute Lung Injury UCB: Platelets Transfusion Refractoriness TRALI: Human Induced Pluripotent Stem Cells PLTs: This review will focus on how to progress of in vitro generation of PLT from stem cell especially iPSCs and some of the successful strategies that can be easily used in clinic will be described. Due to new advances in development of MK cell lines, bioreactors, feeder cell-free production and the ability of large scale generation, iPSC-based PLTs are moving toward clinical applicability and considering the minimal risk of alloimmunization and tumorigenesis of these products, there is great hopefulness they will become the standard source for blood transfusions in the future. Moreover, iPSCs can be acquired from any donor and easily manipulated. They are able to differentiate into any cells and have the capacity of self-renewal. iPSCs are considered as an ideal unlimited source for PLT production. But ESCs have ethical issues related to destroying human embryos. Alternative sources can be ESCs which have unlimited expansion capacity. However, HSCs are a limited source for PLT production and large-scale expansion of HSC-derived PLT remains difficult. Currently several cells have been considered as source to in vitro production of PLTs such as hematopoietic stem cells (HSCs), embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Overcoming these obstacles is possible with in vitro production of human PLTs. PLT transfusion is donor‐dependent way which have limitations including the inadequate donor blood supply, poor quality, and issues related to infection and immunity. PLT transfusion is standard therapy to prevent hemorrhage. An increased understanding of the fundamental mechanisms underlying pluripotency and refining the methodology of iPS cell generation will have a profound impact on future development and application in regenerative medicine and reproductive biotechnology of farm animals.Ĭhimera Gene delivery Germline transmission Induced pluripotent stem cells Large animal models Reprogramming Stemness.Platelets (PLTs) are small anucleate blood cells that release from polyploidy megakaryocytes(MKs). We also highlight problems associated with the generation of iPS cells. In this review, we focus on the mechanisms of cellular reprogramming and current methods used to induce pluripotency. Non-integration methods have been reported to overcome the safety concerns associated with retro and lentiviral-derived iPS cells, such as transient expression of the reprogramming factors using episomal plasmids, and direct delivery of reprogramming mRNAs or proteins. Multiple viral integrations into the genome may cause insertional mutagenesis and may increase the risk of tumour formation. Most induced pluripotent stem (iPS) cells are generated by retroviral or lentiviral transduction of reprogramming factors. The recently established technology to generate an induced pluripotency status by ectopic co-expression of the transcription factors Oct4, Sox2, Klf4 and c-Myc allows to extending these applications to farm animal species, for which the derivation of genuine embryonic stem cells was not successful so far. Via blastocyst complementation, pluripotent cells are a favoured tool for the generation of genetically modified mice. Pluripotent cells also allow to study developmental pathways, and to employ them or their differentiated cell derivatives in pharmaceutical testing and biotechnological applications. These features provide the basis for an unlimited cell source for innovative cell therapies. Pluripotent stem cells are unspecialized cells with unlimited self-renewal, and they can be triggered to differentiate into desired specialized cell types. 8/27/2023 0 Comments Minitube canine extender![]() Recently, research has highlighted their potential role in repair mechanisms occurring at cellular level 19. Mesenchymal stem cells (MSCs) are believed to be an integral part of regenerative medicine. Therefore, the repair of injured sperm could be a determining factor for improving the fertility of canine using frozen semen. In addition, the chemical additives used for supplementation have been also associated with the issues of cytotoxicity 8, 18. The reasons behind the lower fertility of frozen semen may be the primary or secondary damaged sperm that requires immediate regeneration and recovery. However, the rates of whelping using cryopreserved semen (50.0–70.8%) are still lower in comparison with the fresh semen (81.8–83.7%) 17. These changes ultimately contribute to an overall reduction in the fertility of sperm.Ĭurrent protective modifications employed to minimize the above mentioned damaging effects involve the use of different types of extenders 9, variations in the freezing protocols 10, and supplementation of extenders with nutrients or antioxidants 11, 12, 13, 14, 15, 16. In addition, the activation of apoptotic pathways results in the fragmentation of sperm cell DNA 8. The sperm that survives during freezing procedure suffers a reduction in fertility 6 and this has been linked with damage that adversely affects viability, motility, plasma membrane, acrosome and chromatin material 7. Sperm undergoes certain detrimental changes at the structural and molecular levels as a result of thermal, mechanical, osmotic, and oxidative damage 4, 5. During freezing the quality-related traits of sperm are highly compromised 3. In addition, it has greatly benefited the animal -based industry by reducing the cost and the stress associated with transportation, overcoming the quarantine restrictions and breeding issues (e.g., aggressive behavior and size issues) 2.ĭespite many attempts to improve freezing agents and techniques, reduction in semen quality still remains the major issue associated with freezing procedures. It can facilitate the storage of the genetic material for an extended period, conserve the elite individual’s fertility and serve as a useful tool for preserving the endangered species. Semen cryopreservation is regarded as the most important step of artificial insemination which is the most widely adopted assisted reproductive technology (ART) in canine practice 1. At an appropriate concentration, Ad -MSCs significantly improve the quality of post-thaw dog sperm. ![]() The results confirm that canine Ad -MSCs can effectively preserve the quality of frozen-thawed sperm by a reduction in cryoinjury. Protein expression of ANX1, H 3, and FN1 was also statistically more in Group 1 than in Control. Additionally, Group 1 showed significantly higher expression levels of genes related to the repair of membranes ( ANX1, dysferlin DYSF, and fibronectin FN1) and chromatin material ( H3 and HMGB). Group 1 exhibited significantly higher post-thaw motility, live sperm, intact plasma membrane and normal acrosomes than the other groups. The washed pooled ejaculates were diluted with buffer 2 (extender) supplemented without Ad -MSCs (Control), with 2.5 × 10 6 Ad -MSCs/mL (Group 1) or with 5 × 10 6 Ad -MSCs/mL (Group 2). ![]() Semen was collected from four healthy dogs by digital manipulation. Canine Ad -MSCs were selected on the basis of the significantly higher gene expression for different proteins actively involved in the cell repair including annexin 1 ( ANX1), histone H3 ( H3) and high mobility group B ( HMGB) protein compared to skin fibroblasts. The objective of this study was to examine the potential of canine adipose -derived mesenchymal stem cells (Ad -MSCs) for providing protection to the dog sperm against cryo-damage. Cryopreservation procedures negatively affect the quality traits of sperm, causing certain changes at structural and molecular levels due to thermal, mechanical, osmotic, and oxidative damage. 8/27/2023 0 Comments Jbl charge 5 vs jbl flip 5![]() But the Charge 5 does bring some impressive specs to the portable party.įirstly, its sonic abilities have been upgraded. JBL Charge 5 vs Charge 4: featuresīluetooth speakers at this price aren't usually bursting with features – there's no wi-fi, for starters, and no support for voice assistants. So, the Charge 5 is a bit bigger, but a lot sturdier. The ends of the Charge 5’s trademark barrel-like bodywork boast a slightly more robust rubberised reinforcement, while the speaker itself is a whole 1mm taller, 2mm deeper, 3mm wider and 5g heavier than its older brother – although there’s little in that to the naked eye. Under a smaller rubber cap, you still get the useful USB-A port for using the Charge 5 to charge your devices. Gone is the 3.5mm port for wired listening, and the new USB-C charging port is uncovered this time. The rubberised underbody now comprises pleasing diagonal lines for traction when you set it down (as first seen on the Go 3), rather than a block of opaque rubber. The Charge 5 has a larger logo, but it looks classier too, less like a badge with simple metallic accents around the letters rather than a block frame. ![]() Author Mr.The Charge range is built to handle the great outdoors – as such, sturdy, chunky build quality is very much the order of the day.ĭesign-wise, there's not much to choose between the two. Yes! Both use the same Partybooth feature and can be linked together. Which JBL speakers are PartyBoost compatible? Yes! Flip 5 and Flip 6 use the same Partybooth feature and can be linked together. Yes, the JBL 5 has Partyboost, the same protocol as the JBL Flip 6 has Frequently Asked Questions about JBL Flip 5 and JBL Flip 6 Head over to Amazon to grab one and get free shipping:Īs an Amazon Associate we earn from qualifying purchases. If you want to save some dough, grab a Flip 5 while they are still available. However, the Flip 6 has better connectivity, and improved durability, making it the better option of the two if price is not an option. Overall, both the JBL Flip 6 and the JBL Flip 5 are excellent Bluetooth speakers that offer powerful, clear sound in a compact package. The Flip 6 isn’t really worth the extra $30 unless you must have the loudest, latest and greatest and want the newer Bluetooth protocol.īoth have the latest Partyboost pairing generation, so you can pair Flip 5 and Flip 6 together, or to other JBL speakers like the JBL Charge 5. PriceĪs of now, both Flip 5 and Flip 6 are in the market, and you can get the Flip 5 for $99.95, or less (if on promo) while the Flip 6 comes in at $129.95. This makes it a great option for outdoor use, as it can withstand splashes and spills. It has an IPX7 rating, which means it can be fully submerged in water for up to 30 minutes. In terms of durability, the Flip 6 is also slightly better than the Flip 5. (Not counting the passive radiators on the sides which both have – those aren’t really speakers.) Durability / Weatherproofing The Flip 6 has 30 watts of power, and 2 speakers, vs 20 watts on the Flip 5 with a single speaker. However, the Flip 6 has a more powerful amplifier and larger drivers, which means it can produce louder, more dynamic sound than the Flip 5. ![]() In terms of sound quality, both speakers offer powerful, clear sound with deep bass. ![]() This means you can enjoy uninterrupted music playback, even if you move the speaker further away from your device. The Flip 6 has Bluetooth 5.1, which provides a faster and more stable connection to your devices than the Flip 5’s Bluetooth 4.2. ConnectivityĪnother key difference is the connectivity options. The Flip 6 has a similar battery life to the Flip 5, with a playtime of up to 12 hours on a single charge. It has a new, bolder logo, a different grill weave, and all around better molding. The Flip 6 has been redesigned, and in my opinion it was very well done, and out of the two speakers, I prefer the 6. However, there are some key differences between the two models that may influence your decision when choosing between them. The JBL Flip 6 and the JBL Flip 5 are both portable Bluetooth speakers that are ideal for on-the-go listening given their easy to carry size – similar to a large can of beer.īoth speakers have a similar design and offer powerful, clear sound in a compact package. 8/27/2023 0 Comments Pere marquette 1225![]() Here is another close up of the drivers and partial cab taken by an unknown photographer in his/her study of the beautiful but sadly bird stained display at Michigan State University before it was reborn as the "Polar Express" prototype. An unknown photographer did the photo slide study. Now it is the famous "Polar Express" loco as it served as the prototype for the Disney movie. Originally it was Pere Marquette #1225 but absorbed into the C&O roster in 1947. The date is approximate.Īnother closeup view of the stately 1941 Lima built 2-8-4 Berkshire drivers and bird droppings while it was on display at Michigan State University. Its story after this point is an interesting one with many dramatic moments and the dedication by a group of rail activists originally from the university. An unknown photographer did a photo slide study of this beautiful machine while on static display at Michigan State University. This loco was restored and served as the prototype for the children's story, "The Polar Express." No photographer name was given for this photo slide study and the date is approximate.Īnother close up view of the drivers on this 1941 Lima built 2-8-4 Berkshire, orginally Pere Marquette #1225 but absorbed into the C&O roster in 1947. The date is approximate.Īnother closeup view of the drivers on the 1941 Lima built 2-8-4 Berkshire #1225 built originally for the Perl Marquette but merged into the C&O roster in 1947. An unknown photographer created this interesting study of the locomotive. ![]() Part of the photo study of the 1941 Lima built 2-8-4 Chesapeake & Ohio #1225, nee-Pere Marquette, while on display at Michigan State University. Unknown photographer and the date is approximate. The mighty face of this 1941 Lima built 2-8-4 Bershire in this interesting photo study of the locomotive while on display at Michigan State University. ![]() Unknown photographer of the photo study and the date is approximate. Date is approximate and no photographer name was given.Ĭlose up of the pilot on the C&O 2-8-4 #1225, nee-Pere Marquette #1225 while on display at Michigan State University. Stylish profile of the 1941 Lima built 2-8-4 #1225 originally Pere Marquette but eventually Chesapeake & Ohio #1225 while it was on display at the Michigan State University. ![]() This was part of an interesting photo study of the C&O 2-8-4, nee-Pere Marquette #1225 by an unknown photographer while it was on display at the Michigan State University. Part of the slide series by an unknown photographer of the display plaque by the 1941 Lima built PM 2-8-4 #1225 while wearing the C&O name.Ĭlose-up of the engineer's cab window of this now famous locomotive. It was fully restored to its original Pere Marquette state and served as the porototype model for "The Polar Express" locomtoive. Here is another full side view in the slide series taken by an unknown photographer of the 1941 Lima built 2-8-4 while on dispaly as C&O 1225. These slides appear to be an unusual study in the parts of this loco while on display at the Michigan State University before it was restored. From there, the loco's history takes many dramatic turns eventually ending up as the famous Christmas train. Built by Lima in October of 1941 as Pere Marquette #1225, it eventually ended up on the C&O steam roster in 1947 merger. Here is the now famous Pere Marquette 2-8-4 #1225 of Polar Express fame before its rebirth. Pere Marquette #1225 pulling a freight east in 1950 Just days old, 1225 is on PM rails after just having been delivered 8/27/2023 0 Comments Business receipts scanner![]() Lastly, after the expense summary page, which is the top page of the expense report, the receipt images are attached. If more than one receipt has the same date, then the end of the system generated name is appended is a number, starting with one. The receipt is named by the date entered by the user for the receipt. Inside each expense report is a column dedicated for a system-generated receipt name. Further, receipt logs are exported in organized expense reports. With Falcon Expenses, add the reason or purpose for each business expense directly into the comments field located on the form. Therefore, a better approach is to use a mobile solution like Falcon Expenses. Usually, you would scribble the reason on the back of the receipt then crumple it up and put it in your pocket to be lost later. The expense form is where expense information from the receipt is entered.ĭedicated Field for Expense Purpose (That’s Not the Back of the Receipt)Īdequate record keeping requires a reason is given to deduct certain business expenses. Further, below the receipt image on the bottom half of the screen is the expense form. Receipts uploaded to Falcon Expenses via the Enter Expense form are displayed on the top half of the screen. Falcon Expenses Receipt Management Features Streamlined Entry of Receipt Data If you’re on a desktop it’s best to use your iPhone and search for Falcon Expenses on the app store. You can also add custom tags, purpose, and categories.įalcon Expenses is free to download. Falcon Expenses provides a solution to keep every business expense receipt, along with the amount, date, place, and purpose associated with the receipt images. All receipts are safely stored inside Falcon Expenses. With Falcon Expenses, you capture pictures of receipts as you get them. In any event, by the time you get back to your office, you have likely misplaced many of their receipts. This is more efficient than waiting to get back to the office to enter all of the receipt data into a spreadsheet. All of your receipts are safely stored in one place and can be quickly organized into downloadable reports that can be emailed to anyone, at any time. You simply open their phone and snap pictures of business expense receipts. Use Falcon Expenses to capture pictures of receipts on the go. Falcon’s receipt keeper safely stores proof of the business expense purchase beyond the cryptic details that are found on a credit card statement. Pictures of paper receipts also serve as proof of purchase and are less prone to misplacement or damage. Paper receipts serve as proof of purchase. The basis for an adequate expense record, and receipt management, is if it contains the following information:įor a complete guide of the details on what you need to keep for each expense type, check out this post: IRS Rules for Recording Business Expenses: Travel, Transportation, Meals and Entertainment. Also, transportation expenses that do not readily have a receipt available, don’t require a receipt. Such as, expenses under $75 that are not lodging expenses and do not require a receipt. such as receipts) of individual expenses. Adequate records require that a log of the expenses be kept along with documentary evidence (i.e. Proper recordkeeping is important for preventing an IRS audit and being prepared in the event of an audit. What are IRS receipt recordkeeping requirements? ![]() The entire receipt management process is cumbersome and time-consuming. forget where they’ve put business expense receipts.Īlso, for the paper receipts you haven’t misplaced, you likely need to tape each one to paper and scan and send to your accountant or manager. Often, receipts are required by your accountant or employer for IRS-compliant recordkeeping or reimbursement.ĭelivery drivers, freelancers, small business owners, etc. You likely have experience with misplacing cash receipts if you’re self-employed or an employee that regularly submits expense reports. Receipt Management: The Painful Back Story 8/27/2023 0 Comments Vanilla blonde latte![]()
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